Main
XIE, Xin-hui
Currently seeking an Assistant Professor, Postdoctoral Researcher, Scientist, or other scientific position.
The intricacies of the central nervous system pose challenges in studying neuro-psychiatric disorders. A recent technique involving the enrichment of brain-derived extracellular vesicles (BDEVs) from peripheral blood can provides direct in vivo CNS data, bypassing the blood-brain barrier. However, for those rapidly changing CNS disorders like encephalitis, depression, bipolar disorder, and others, the standard biometric sampling frequency (half-yearly or yearly) falls short in capturing molecular signaling trajectories, in line with the Nyquist-Shannon sampling theorem.
In response, I innovated a method to isolate BDEVs from urine. Urinary BDEVs enable non-invasive, frequent in vivo CNS signal collection, satisfying Nyquist-Shannon sampling theorem criteria. This advancement facilitates the depiction of intricate paths of CNS-specific molecular signaling linked to these swiftly evolving neuropsychiatric disorders. This, in turn, aids in comprehending disease mechanisms and developing suitable treatment strategies.
Consequently, my aspiration is to secure a suitable position that allows me to delve deeply into neuro-psychiatric disorders using this cutting-edge technique. I am particularly driven to discover novel biological markers, elucidate swift pathological mechanisms, enhance diagnostic strategies, and formulate improved treatment approaches for neuro-psychiatric disorders.
Education
Wuhan University
Ph.D. candidate in Psychiatry
Wuhan, China
2021 - 2024
Main research contents:
Investigating the status of neuroinflammation and neurogenesis in patients with major depressive disorder (MDD) using plasma/serum astrocyte-derived extracellular vesicles (ADEVs) and neuro-derived EVs (NDEVs), and the changes before and after electroconvulsive therapy (ECT). The advantage of these brain-derived extracellular vesicles (BDEVs) is that they directly reflect the in vivo changes in the central nervous system (CNS), and are considered to be “windows to the brain”.
Based on the two-hit hypothesis of depression, I designed a new rat model that has the advantages of stable modeling effect and can better simulate the damage of neural synapses and neurotransmitter pathways such as GABA in patients with depression.
Anhui Medical University
M.S. in Psychiatry.
Hefei, China
2011 - 2014
Main research contents:
Schizophrenia patients have similar basic saccade parameters to healthy controls during visually guided saccade, such as amplitude, duration, latency, and accuracy rate. However, I designed an algorithm called the asymmetric acceleration index (AAI) to compute the asymmetry of saccade acceleration. I found that schizophrenia patients had a significantly lower correlation coefficient (RAD) between AAI and saccade duration than healthy controls (Cui et al., 2014).
Anhui Medical University
M.D. equivalent
Hefei, China
2005 - 2010
Professional Experience
Director (Full-time (2017-2021)/Part-time (2021-Now))
Brain Function and Psychosomatic Medicine Institute, Huizhou Mental Health Center (Second People’s Hospital of Huizhou)
Huizhou, China
2017 - Now
- Innovative ECT Strategy: Created Hybrid-ECT, a pioneering approach combining efficacy of standard ECT with reduced cognitive side effects. And further evolved into iHECT, currently in progressive stages.
- Schizophrenia and CAC: Uncovered increased coronary artery calcium (CAC) in schizophrenia patients through COVID-19 chest CT analysis. Identified potential risk factors including elevated triglycerides and decreased Triiodothyronine (manuscript under review).
- Gut Microbiota in Mood Disorders: Explored gut microbiota in patients with major depressive or bipolar disorder, highlighting distinctive microbiota patterns and links to the gut microbial tryptophan biosynthesis and metabolism pathway (MiTBamp).
- Additional Research Endeavors: Engaged in meta-analysis of MRI network topology in depression patients.
Psychiatrist
Department of Psychiatry, Shenzhen Mental Health Center (Shenzhen Kangning Hospital)
Shenzhen, China
2014 - 2017
- Residency training program.
Publications
ORAL: ISOLATING URINARY ASTROCYTE-DERIVED EXTRACELLULAR VESICLES (UADEVS): A NOVEL HIGH-FREQUENCY AND NON-INVASIVE “LIQUID-BIOPSY” APPROACH TO STUDYING CNS DISEASES
The 23rd WPA World Congress of Psychiatry
Vienna, Austria
2023
Xie, X. H.#*, Chen, M.M., Xu, S.X., Mei, J., Song, X.H., Liu, Z.
ORAL: NEUROGENESIS HYPOTHESIS OF DEPRESSION AND ELECTROCONVULSIVE THERAPY (ECT): HUMAN IN VIVO EVIDENCE FROM PLASMA NEURON-DERIVED EXTRACELLULAR VESICLES (NDEVS)
The 23rd WPA World Congress of Psychiatry
Vienna, Austria
2023
Xie, X. H.#*, Xu, S., Yao, L.H., Chen, M.M. Liu, Z.
ORAL:MISFORTUNES NEVER COME SINGLY: A NOVEL RAT MODEL OF DEPRESSION BASED ON THEINSOMNIA-INFLAMMATION TWO-HIT HYPOTHESIS
The 23rd WPA World Congress of Psychiatry
Vienna, Austria
2023
Mei, J.#, Song,X.#, Xie, X. H., Wang, Y. , Wang, G., Chen, C., Xu, S.X., Zhang, H., Chen, G., Liu, Z.*
Trajectories of Efficacy and Cognitive Function During Electroconvulsive Therapy Course in Young Adults with Treatment-Resistant Depression.
Neuropsychiatric disease and treatment, 19, 267–281. DOI PMID
N/A
2023
Xu, S. X.#, Xie, X. H.#, Yao, L., Chen, L. C., Wan, Q., Chen, Z. H., & Liu, Z.* (Comment: XXXX)
Young Adults with Major Depression Show Altered Microbiome.
Neuroscience, 522, 23–32. DOI PMID
N/A
2023
Chen, M. M.#, Wang, P., Xie, X. H., Nie, Z., Xu, S. X., Zhang, N., Wang, W., Yao, L., & Liu, Z.*
Assessment of brain imaging and cognitive function in a modified rhesus monkey model of depression.
Behavioural brain research, 445, 114382. DOI PMID
N/A
2023
Chen, G.#, Ma, S.#, Gong, Q.#, Xie, X. H., Wu, P., Guo, W., Kang, L., Li, M., Zhang, H., Zhou, E., Zhang, Y., Rong, J., Duan, H., Jin, L., Xu, S., Zhang, N., Sun, S., Li, R., Yao, L., Xiang, D., … Liu, Z.*
Inflammatory bowel disease and the long-term risk of depression: A prospective cohort study of the UK biobank.
General hospital psychiatry, 82, 26–32. DOI PMID
N/A
2023
Ma, S.#, Wang, W., Gong, Q., Xiang, D., Yao, L., Xu, S., Xie, X. H., Wang, H., Wang, G., Yang, J., & Liu, Z.*
Hyper-inflammation of Astrocytes in Patients of Major Depressive Disorder: Evidence from Serum Astrocyte-derived Extracellular Vesicles.
Brain, behavior, and immunity, 109, 51–62. DOI PMID
N/A
2023
Xie, X. H.#, Lai, W. T., Xu, S. X., Forti, M. D., Zhang, J. Y., Chen, M. M., Yao, L. H., Wang, P. L., Hao, K. K., & Han, R.* (Comment: XXXX)
Measuring childhood trauma in young adults with depression: A latent profile analysis.
Asian journal of psychiatry, 109, 51–62. DOI PMID
N/A
2022
Wang, P.#, Xie, X. H., Chen, M., Zhang, N., Wang, W., Ma, S., Nie, Z., Yao, L., & Liu, Z.*
The relationship between vitamin D levels in seasonal variations and Chinese patients with first-episode drug-naive depression.
Journal of psychosomatic research, 164, 111079. DOI PMID
N/A
2022
Yao, L.#, Zhang, N., Ma, S., Xie, X. H., Xu, S., Xiang, D., Kang, L., Chen, M. M., Wang, P., & Liu, Z.*
Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation.
Journal of neuroinflammation, 19(1), 232. DOI PMID
N/A
2022
Hao, K.#, Wang, H.#, Zhang, Y.#, Xie, X. H., Huang, H., Chen, C., Xu, S., Xu, R., Shu, C., Liu, Z., Zhou, Y., Reynolds, G. P., & Wang, G.*
Electroconvulsive Therapy in a Young Adult Patient With Bipolar Depression and Dysembryoplastic Neuroepithelial Tumor: A Case Report.
The journal of ECT, 10.1097/YCT.0000000000000876. DOI PMID
N/A
2022
Xu, S. X.#, Xie, X. H.#, Su, D., & Liu, Z.* (Comment: XXXX)
Analysis of Psychological and Gut Microbiome Characteristics in Patients With Non-erosive Reflux Disease.
Frontiers in psychiatry, 12, 741049. DOI PMID
N/A
2022
Yang, F.#, Xie, X. H.#, Li, X., Liao, H. N., & Zou, B.* (Comment: XXXX)
Functional Connectivity Features of Resting-State Functional Magnetic Resonance Imaging May Distinguish Migraine From Tension-Type Headache.
Frontiers in neuroscience, 16, 851111. DOI PMID
N/A
2022
Wang, Y.#, Wang, Y., Bu, L., Wang, S., Xie, X. H., Lin, F., & Xiao, Z.*
Improved Safety of Hybrid Electroconvulsive Therapy Compared With Standard Electroconvulsive Therapy in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Parallel-Group Pilot Trial.
Frontiers in psychiatry, 13, 896018. DOI PMID
N/A
2022
Zhang, J. Y.#, Xu, S. X.#, Zeng, L.#, Chen, L. C., Li, J., Jiang, Z. Y., Tan, B. J., Gu, C. L., Lai, W. T., Kong, X. M., Wang, J., Rong, H., & Xie, X. H.*
The integrated understanding of structural and functional connectomes in depression: A multimodal meta-analysis of graph metrics.
Journal of affective disorders, 295, 759–770. DOI PMID
N/A
2021
Xu, S. X.#, Deng, W. F.#, Qu, Y. Y.#, Lai, W. T., Huang, T. Y., Rong, H., & Xie, X. H.*
The prevalence and independent influencing factors of obesity and underweight in patients with schizophrenia: a multicentre cross-sectional study.
Eating and weight disorders: EWD, 26(5), 1365–1374. DOI PMID
N/A
2021
Wang, J.#, Zhang, Y., Yang, Y., Liu, Z., Xia, L., Li, W., Li, Z., Xie, X. H., Deng, W., Zhang, K., & Liu, H.*
Higher prevalence of coronary artery calcification in schizophrenia patients.
Schizophrenia research, 231, 47–48. DOI PMID
N/A
2021
Huang, T. Y.#, Deng, W. F.#, Li, X. P., Chen, H. Q., Xu, S. X., Ke, S. H., & Xie, X. H.*
The efficacy and acceptability of hybrid electroconvulsive therapy compared with standard electroconvulsive therapy for schizophrenia patients: A parallel-group, double-blind, randomized, controlled trial.
Brain stimulation, 14(3), 737–739. DOI PMID
N/A
2021
Li, J.#, Deng, W. F.#, Xu, S. X.#, Jiang, Z. Y., Rong, H., Kong, X. M., & Xie, X. H.*
Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in bipolar disorder with current major depressive episode patients.
Journal of affective disorders, 278, 311–319. DOI PMID
N/A
2021
Lai, W. T.#, Zhao, J.#, Xu, S. X.#, Deng, W. F.#, Xu, D., Wang, M. B., He, F. S., Liu, Y. H., Guo, Y. Y., Ye, S. W., Yang, Q. F., Zhang, Y. L., Wang, S., Li, M. Z., Yang, Y. J., Liu, T. B., Tan, Z. M., Xie, X. H.*, & Rong, H.*
Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients.
Psychological medicine, 51(1), 90–101. DOI PMID
N/A
2021
Lai, W. T.#, Deng, W. F.#, Xu, S. X.#, Zhao, J., Xu, D., Liu, Y. H., Guo, Y. Y., Wang, M. B., He, F. S., Ye, S. W., Yang, Q. F., Liu, T. B., Zhang, Y. L., Wang, S., Li, M. Z., Yang, Y. J., Xie, X. H.*, & Rong, H.*
眼脑联动与神经精神疾病[Initiative of eye-brain joint computing in neuropsychiatric disorders].
中华精神科杂志,053(006), 546-552. DOI
N/A
2020
谢新晖 (Xie, X. H.)#, Bang Chen#, 赵一天, 王浩, 徐淑娴, 胡衍, 荣晗, 刘江*
Short-term effects of air pollution on cause-specific mental disorders in three subtropical Chinese cities.
Environmental research, 191, 110214. DOI PMID
N/A
2020
Li, H.#, Zhang, S., Qian, Z. M., Xie, X. H., Luo, Y., Han, R., Hou, J., Wang, C., McMillin, S. E., Wu, S., Tian, F., Deng, W. F.*, & Lin, H.*
The effect of temperature on cause-specific mental disorders in three subtropical cities: A case-crossover study in China.
Environment international, 143, 105938. DOI PMID
N/A
2020
Zhang, S.#, Yang, Y., Xie, X. H., Li, H., Han, R., Hou, J., Sun, J., Qian, Z. M., Wu, S., Huang, C., Howard, S. W., Tian, F., Deng, W., & Lin, H.*
Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression.
BMC psychiatry, 19(1), 344. DOI PMID
N/A
2019
Rong, H.#, Xu, S. X.#, Zeng, J.#, Yang, Y. J., Zhao, J., Lai, W. T., Chen, L. C., Deng, W. F., Zhang, X., Zhang, Y. L., Li, M. Z., Xiao, L., & Xie, X. H.*
Low-Charge Electrotherapy in Geriatric Major Depressive Disorder Patients: A Case Series.
Psychiatry investigation, 16(6), 464–468. DOI PMID
N/A
2019
Kong, X. M.#, Xie, X. H., Xu, S. X., Chen, Y., Wang, C., Hong, H., & Sun, Y.*
Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients.
Journal of psychiatric research, 113, 90–99. DOI PMID
N/A
2019
Rong, H.#, Xie, X. H.#, Zhao, J., Lai, W. T., Wang, M. B., Xu, D., Liu, Y. H., Guo, Y. Y., Xu, S. X., Deng, W. F., Yang, Q. F., Xiao, L., Zhang, Y. L., He, F. S., Wang, S., & Liu, T. B.*
Low-charge electrotherapy for patients with schizophrenia: A double-blind, randomised controlled pilot clinical trial.
Psychiatry research, 272, 676–681. DOI PMID
N/A
2019
Li, M. Z.#, Chen, L. C.#, Rong, H., Xu, S. X., Li, Y., Yang, Q. F., Deng, W. F., Yang, H. Z., Kong, X. M., Xiao, L., & Xie, X. H.*
Electroconvulsive therapy changes the regional resting state function measured by regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in elderly major depressive disorder patients: An exploratory study.
Psychiatry research. Neuroimaging, 264, 13–21. DOI PMID
N/A
2017
Kong, X. M.#, Xu, S. X.#, Sun, Y., Wang, K. Y., Wang, C., Zhang, J., Xia, J. X., Zhang, L., Tan, B. J., & Xie, X. H.*
Mindfulness-based stress reduction for chronic insomnia in adults older than 75 years: a randomized, controlled, single-blind clinical trial.
Explore (New York, N.Y.), 11(3), 180–185. DOI PMID
N/A
2015
Zhang, J. X.#, Liu, X. H.#, Xie, X. H.*, Zhao, D., Shan, M. S., Zhang, X. L., Kong, X. M., & Cui, H.*
Efficacy and acceptability of atypical antipsychotics for the treatment of post-traumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.
Psychiatry research, 219(3), 543–549. DOI PMID
N/A
2014
Liu, X. H.#, Xie, X. H.*, Wang, K. Y., & Cui, H.*
Association of saccade duration and saccade acceleration/deceleration asymmetry during visually guided saccade in schizophrenia patients.
N/A
2014
Cui, H.#, Liu, X. H.#, Wang, K. Y., Zhu, C. Y., Wang, C., & Xie, X. H.*
Electroconvulsive therapy on severe obsessive-compulsive disorder comorbid depressive symptoms.
Psychiatry investigation, 11(2), 210–213. DOI PMID
N/A
2014
Liu, X.#, Cui, H.#, Wei, Q., Wang, Y., Wang, K., Wang, C., Zhu, C., & Xie, X. H.*
精神分裂症患者在视觉引导眼跳中速度非对称性与眼跳幅度的相关分析. [The correlation between saccade velocity asymmetry and amplitude during visually guided saccade was lower in schizophrenia patients].
中华精神科杂志, (5), 5. DOI
N/A
2020
谢新晖 (Xie, X. H.)#, 刘晓慧, 王晨, 朱春燕, 崔红, & 王克永*